Lynch综合征|病症| UCSF Health-十大赌博平台排行榜

Overview

Some families have multiple relatives who have 结肠癌或者其他类型的癌症. 这些癌症可能是由一种罕见的遗传性遗传病林奇综合症引起的, also known as hereditary nonpolyposis colorectal cancer (HNPCC). Lynch syndrome significantly increases your chance of developing 结肠癌, and often earlier than the general population – before the age of 45. Nearly 3 percent of all 结肠癌s are caused by Lynch syndrome. It may also increase your risk of other cancers, such as endometrial and 卵巢癌 in women.

The good news is that genetic screening and testing, 在各大医疗中心都有, detects Lynch syndrome in an estimated 95 percent of people.

By determining whether you and your family members have Lynch syndrome, you can take steps to seek appropriate medical care and surveillance, such as regular and consistent colonoscopies and check-ups at earlier ages. This can help to detect and prevent cancer, and ultimately, to save lives.

我们治疗Lynch综合征的方法

UCSF offers comprehensive genetic counseling for families with a history of cancer. Our goal is to help you manage your cancer risk. If you need to be screened for Lynch syndrome, our team can assess your personal and family history, 如果合适的话, 进行基因测试.

如果你有测试的话, genetic counselors and doctors will design a risk management program for you. It will include individualized recommendations for cancer screening, guidance on prevention and options for treatment. 我们还会建议您如何与其他可能有风险的家庭成员分享这些信息.

Awards & recognition

是全国顶尖的十大赌博平台排行榜之一
北加州最好的，排名第一. 全国癌症治疗排名第七
指定综合癌症中心

Signs & symptoms

林奇综合症患者可能有:

结肠癌 that occurs at a young age, especially before age 45
家族病史结肠癌 that occurs at a young age
家族病史子宫内膜癌
家族病史 other related cancers, including 卵巢癌, 肾癌, 胃癌小肠癌; 肝癌或者其他癌症

患有林奇综合症的人在70岁之前患结肠癌的几率为70%. 据估计，Lynch综合征结肠癌患者在第一次肿瘤确诊后的七年内有40%的风险发展为第二次原发性结肠癌. 患有Lynch综合征的女性一生中患子宫内膜癌的风险估计为40%到60%.

Lynch syndrome may also increase a person's risk for cancers of the stomach, ovary, 尿路, 肝胆的束, brain, 小肠, 皮肤和胰腺.

Diagnosis

如果你有癌症家族史，让你的十大赌博平台排行榜知道是非常重要的. Your doctor will then take a thorough recording of your family history, paying particular attention to cancer diagnoses. If your doctor suspects that you may have Lynch syndrome, 他们会把你介绍给专门从事基因癌症筛查的医疗保健专家, 测试和咨询.

In addition, 所有新诊断的结直肠癌或子宫内膜癌患者也应进行林奇综合征的筛查或检测.

基因检测

Genetic testing involves a simple blood test. 你的血液样本被送到一个特殊的实验室，在那里它被分析某些变化或突变，表明林奇综合症.

如果你的林奇综合症检测呈阳性, meaning that genetic mutations were found in your blood, this does not necessarily mean that you will get cancer. 这意味着你一生中患结肠癌的风险在60%到80%之间. 你患上与林奇综合症相关的其他癌症的几率也会增加.

林奇综合症的检测结果为阴性, meaning that genetic mutations were not found in your blood, 取决于其他因素，比如你的家庭成员是否患有林奇综合症或结肠癌. If you test negative for Lynch syndrome but have family members with the syndrome, 你患结肠癌的风险不会增加, but remains the same as the general population. However, 在某些情况下, such as if you have a strong family history of 结肠癌, 一个阴性的测试结果可能仍然意味着你患结肠癌的风险增加.

您的遗传咨询师将解释您的测试结果，并帮助您做出有关癌症预防的决定, 筛查和治疗方案.

哪些人应该接受筛查或检测

根据既定的医疗标准, the following people should be screened or tested for Lynch syndrome:

Newly diagnosed colorectal or 子宫内膜癌 patients 林奇综合征诊断的第一步是评估肿瘤与林奇综合征相关的分子特征. 当肿瘤无法进行筛查时, 如果你的家族史和癌症诊断强烈显示患有Lynch综合征，那么就可以进行DNA血液检测. UCSF's Cancer Genetics and Prevention Program, in conjunction with our Gastrointestinal Cancer Prevention Program, offers a unique service to all colorectal cancer and 子宫内膜癌 patients. 我们会在病人做结直肠癌或子宫内膜癌手术时自动筛选林奇综合症. Patients who screen positive are then referred for genetic counseling and testing.
Patients diagnosed with more than one Lynch syndrome-related cancers 如果你被诊断患有多种与Lynch综合征相关的癌症包括结肠直肠癌, endometrial, ovarian, gastric, small bowel, 上尿路, 肝胆的束, pancreas, 大脑和皮脂腺的肿瘤, you should be screened or tested for Lynch syndrome.
Patients with a family history of colorectal or 子宫内膜癌 If you have two or more relatives with colorectal or 子宫内膜癌, particularly if one was affected before age 50, you should be screened or tested for Lynch syndrome.

Treatments

根据你的家族史, genetic testing results and other cancer risk factors, 你的咨询师和十大赌博平台排行榜会为你提供个体化的风险管理方案，包括癌症筛查的建议, 预防和治疗方案.

Cancer Screening for People with Lynch Syndrome

如果你的林奇综合症检测呈阳性, 但没有癌症诊断, or your doctor suspects that you have Lynch syndrome, the following cancer screening plan may be recommended.

结直肠癌筛查

Colonoscopy 每一到两年一次, 从20岁到25岁开始(在有MSH6突变的家庭中是30岁)，或者比家庭中最年轻的诊断年龄小10岁, 先到者为准.

子宫内膜癌筛查

While there is no established screening for 子宫内膜癌 at this time, given the high risk of developing the disease in women with Lynch syndrome, 建议采用以下方法:

子宫内膜活检每年从30岁到35岁开始. 患有Lynch综合征的妇女如报告阴道不规则出血或绝经后出血等异常症状，子宫内膜活检是必要的.
经阴道超声 for endometrial and 卵巢癌每年从30岁到35岁开始.
Urinalysis with cytology 每一到两年一次 beginning at age 25 to 35.
详细的病史和检查, education and counseling regarding Lynch syndrome every year beginning at age 21.

Treatment for Cancer Patients with Lynch Syndrome

对于Lynch综合征检测呈阳性的结直肠癌患者，可能会建议进行手术，以防止其他癌症的发生. For instance, if you have colorectal cancer and test positive for Lynch syndrome, 可能建议在结肠癌手术时切除大部分结肠, 哪种方法可以将你患原发性结直肠癌的风险从40%降低到1%. Likewise, 女性结直肠癌患者也可以考虑切除子宫和卵巢，以防止Lynch综合征相关子宫内膜癌和卵巢癌的发生.

你的咨询师和十大赌博平台排行榜可以帮助你决定哪种治疗方案最适合你.

UCSF Health medical specialists have reviewed this information. 它仅用于教育目的，并不打算取代您的十大赌博平台排行榜或其他医疗保健提供者的建议. 我们鼓励您与您的供应商讨论您可能遇到的任何问题或疑虑.